Unraveling Genome Biophysics

Unraveling Genome Biophysics.

While digitizing the human genome has been one of the major recent scientific achievements, unraveling genome structure and, more importantly, structure/function relationships has been a major preoccupation for many scientific teams worldwide. Indeed, the understanding of structure from the DNA level to nucleosomes, chromatin fibers, genes, and chromosomes holds the key to interpreting many of ...

Unraveling the prostate genome.

I t used to be that scientists looking for the genetic roots of cancer could sequence only one DNA molecule at a time. Today, " massively parallel " techniques allow scientists to sequence billions of DNA molecules at once. That's led to a sharp drop in analytical costs and to the ability to sequence entire cancer genomes. In this new wave of genetic research, perhaps 100 cancer genome sequence...

Biophysics.

Unraveling the 3D genome: genomics tools for multiscale exploration.

A decade of rapid method development has begun to yield exciting insights into the 3D architecture of the metazoan genome and the roles it may play in regulating transcription. Here we review core methods and new tools in the modern genomicist's toolbox at three length scales, ranging from single base pairs to megabase-scale chromosomal domains, and discuss the emerging picture of the 3D genome...

Unraveling selection in the mitochondrial genome of Drosophila.

We examine mitochondrial DNA variation at the cytochrome b locus within and between three species of Drosophila to determine whether patterns of variation conform to the predictions of neutral molecular evolution. The entire 1137-bp cytochrome b locus was sequenced in 16 lines of Drosophila melanogaster, 18 lines of Drosophila simulans and 13 lines of Drosophila yakuba. Patterns of variation de...